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KMID : 1123920080220010162
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Korean Journal of Oriental Physiology and Pathology
2008 Volume.22 No. 1 p.162 ~ p.170
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Studies on The Action of Kamisungihwalhyul-tang on DOCA-salt Hypertensive Rat
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Jeon Sang-Yun
Hong Seok
Cho Gook-Ryung
Kim Nam-Uk
Kang Sung-In
Jeung Jong-An
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Abstract
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Kamisungihwalhyul-tang(KSHT) has been used for many years as a therapeutic agent for cerebrovascular disease and hypertension in Oriental Medicine. But the effect of KSHT on hypertension and reactive oxygen is not well-known. This study was examined to investigate the effect of KSHT on hypertension and reactive oxygen. After administering KSHT extract to Sprague- Dawley Rat forinjected subcutaneous with deoxycorticosterone acetate(DOCA) 8 weeks, changes in blood pressure, pulse rate, 2,2-diphenyl-1-picrylhydrazyl, reactive oxygen species, angiotensin converting enzyme, aldosterone, catecholamine levels, electrolyte, uric acid, BUN, creatinine in plasma were examined, and immunohistochemical changes and scanning electron microscopic changes were observed. 2,2-diphenyl-1-picrylhydrazyl(DPPH) scavenging activity was increased, reactive oxygen species(ROS) was decreased in a KSHT concentration-dependent. Angiotensin converting enzyme(ACE) inhibitory activity was increased in a concentration-dependent by KSHT. KSHT significantly decreased the blood pressure and heart rate in DOCA-salt hypertensive rat. KSHT significantly decreased the levels of aldosterone in DOCA-salt hypertensive rat. KSHT significantly decreased the level of dopamine, norepinephrine, epinephrine in DOCA-salt hypertensive rat. , and Cl- were decreased significantly, was increased significantly by KSHT. KSHT significantly decreased uric acid, BUN, creatinine.
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KEYWORD
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Kamisungihwalhyul-tang(加味順氣活血湯), hypertension, DOCA-salt, antioxidant effect, catecholamine, electrocytes, plasma hormone
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